COMPUTATIONAL EVALUATION AND BENCHMARK STUDY OF 342 CRYSTALLOGRAPHIC HOLO-STRUCTURES OF SARS-COV-2 MPRO ENZYME

Computational evaluation and benchmark study of 342 crystallographic holo-structures of SARS-CoV-2 Mpro enzyme

Abstract The coronavirus disease 19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis with abandonado extra anejo millions of confirmed cases and related deaths.The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication and presents an attractive target for drug developm

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Reasoned opinion on the review of the existing maximum residue levels (MRLs) for acibenzolar-S-methyl according to Article 12 of Regulation (EC) No 396/2005

According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide acibenzolar-S-methyl.In order to assess the occurrence of acibenzolar-S-methyl residues in plants, processed commodities, rotational crops and live

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c-FLIP degradation mediates sensitization of pancreatic cancer cells to TRAIL-induced apoptosis by the histone deacetylase inhibitor LBH589.

magnolia parka Great efforts have been made to develop novel and efficacious therapeutics against pancreatic cancer to improve the treatment outcomes.Tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) is such a therapeutic cytokine with selective killing effect toward malignant cells.However, some human pancreatic cancers are intrinsic

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